Polynucleotides
Polynucleotides are regenerative injections that hydrate the skin and improve its quality. Typically €200–350 in Estonia — dozens of clinics offer them.
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Polynucleotides are a modern regenerative injectable procedure in which substances made of purified DNA fragments are delivered into the skin, stimulating its own repair processes, hydrating it deeply and improving its overall quality. Unlike dermal fillers, they do not add volume — they restore the skin's elasticity and health. In our directory, dozens of clinics across Estonia offer polynucleotide treatments, with providers in both Tartu and Tallinn.
What are polynucleotides and how do they affect the skin?
Polynucleotides are long-chain molecules made up of purified, fragmented DNA particles. The polynucleotides used in aesthetic procedures are mostly derived from the gametes of highly purified fish (salmon or trout, for example), which is why they are so well tolerated by human skin.
Once in the skin, polynucleotides act as a biostimulator: they switch on fibroblast activity, encourage collagen and elastin production, and bind water, delivering deep hydration. They also have an antioxidant and anti-inflammatory effect that helps the skin heal better.
Unlike hyaluronic acid fillers, the aim of polynucleotides is not to add volume or fill wrinkles, but to improve the quality, elasticity and hydration level of the skin from within. For that reason they are often described as a skin bioremodelling or biostimulation procedure.
Which areas are polynucleotides used on?
The most common treatment area is the face, where polynucleotides improve the skin's texture, tone and hydration and soften fine lines. They are used in particular to revive dry, tired, dull or prematurely ageing skin, where conventional skincare no longer delivers enough of a result.
Polynucleotides are very popular around the eyes, where the thin, delicate skin gains extra hydration and elasticity, helping to soften dark circles and fine lines. The neck, décolletage and backs of the hands are also frequently treated, as signs of ageing appear there early.
On the scalp, polynucleotides are used in cases of hair thinning, to improve the scalp environment and support the hair follicles. For each area, the specialist selects a suitable product and injection technique.
Who is the procedure for, and when should it be avoided?
Polynucleotides suit people whose skin is dry, dehydrated or dull, or has lost elasticity, as well as those who are noticing the first signs of ageing and want a natural, gradual result without changing their facial features. The procedure is also often chosen to ease dark circles under the eyes and a tired-looking gaze.
The procedure is not performed during pregnancy or breastfeeding, or in cases of active skin infection, inflammation or autoimmune disease. Because many of the products are fish-derived, it is important to tell your specialist about any fish allergy, which may be a contraindication.
Before the procedure, the specialist assesses the condition of your skin and your expectations and draws up a suitable treatment plan. Polynucleotide injections are performed only by appropriately trained specialists in a medical setting.
How the procedure goes, the result and aftercare
A single polynucleotide session usually takes 30–45 minutes. The specialist cleanses the skin, often applies a numbing cream, and injects the product evenly into the treatment area using fine needles. For the best result, a course of two to three procedures spaced 3–4 weeks apart is usually done.
The result appears gradually over several weeks, as the skin starts producing new collagen and its hydration level improves. The skin becomes livelier, smoother and healthier in tone, and the result usually lasts 6–9 months, after which a top-up procedure is recommended.
After the injections there may be mild redness, swelling or small bumps at the injection sites, which usually disappear within a couple of days. For the first few days, avoid make-up on the treated area, the sauna, the solarium, intense exercise and alcohol, and use gentle skincare products.
Polynucleotide prices in Estonia
A polynucleotide procedure in Estonia usually costs €200–350 per session. The price depends on the product used, the size of the treatment area and the clinic's location – prices in Tallinn and Tartu are generally slightly higher than in smaller towns.
Since achieving the desired result usually takes several sessions, many clinics offer course packages, which work out cheaper per procedure than single visits. Prices for eye-area and full-face treatments can differ because of the size of the area.
You will find exact prices and package contents on each clinic's entry in our directory, where you can compare providers and book a suitable time.
Frequently asked questions
What is the difference between polynucleotides and hyaluronic acid fillers?
Fillers add volume to the skin and fill wrinkles, whereas polynucleotides improve the skin's quality, elasticity and hydration from within, without changing your facial features. The two are often used for different purposes, and sometimes together.
What are polynucleotides made from?
The polynucleotides used in aesthetic procedures are mostly derived from the gametes of highly purified fish, such as salmon or trout. If you have a fish allergy you must tell your specialist, because it may be a contraindication.
How much does a polynucleotide procedure cost in Estonia?
A polynucleotide procedure in Estonia usually costs €200–350 per session. Course packages often work out cheaper per session, and prices in Tallinn and Tartu are generally slightly higher.
How many procedures are needed and how long does the result last?
A course of two to three sessions spaced 3–4 weeks apart is usually recommended. The result appears gradually and usually lasts 6–9 months, after which a top-up procedure is recommended.
Are polynucleotides suitable for dark circles under the eyes?
Yes, the eye area is one of the most popular treatment areas, because polynucleotides hydrate the thin skin there and improve its elasticity. This helps soften dark circles and a tired-looking gaze, although the result appears gradually.
Is the procedure painful, and what is the recovery time?
Fine needles are used during the procedure, often together with a numbing cream, so discomfort is minimal. Afterwards there may be redness, mild swelling or small bumps, which usually disappear within a couple of days.