Microneedling and mesotherapy — what's the difference

Microneedling and mesotherapy have grown sharply in popularity at Estonian beauty clinics in recent years. The reason: the results are visible, the risks low and the procedure does not require a long recovery. In this guide we explain the difference, who each suits and what to expect.

Microneedling — how it works

A Dermapen or Microneedling RF device creates thousands of microscopic channels in the skin (0,25–2,5 mm deep). The body reacts to this as a micro-injury and triggers a regeneration process: the production of new collagen and elastin fibres. The result: skin structure, tone, pore size and the appearance of scars all improve.

Two main devices in Estonia:

• Dermapen (mechanical): classic microneedling. Suited to acne scars, pores and fine lines.
• Microneedling RF (Vivace, Morpheus8, INTRAcel): combines microneedling with radiofrequency. It penetrates deeper and the results last longer. The price is 30–50% higher.

Mesotherapy — how it works

Mesotherapy is the injection of a cocktail directly into the skin with fine needles. The cocktail's composition is tailored to the goal:

• Hyaluronic acid: hydration, smooth skin. The most common.
• Peptides and growth factors: anti-aging, collagen.
• Vitamins (A, B, C, E): antioxidants, glow.
• PRP (platelet-rich plasma): the client's own blood. The “vampire facial”. Effective for scars.

Who microneedling / mesotherapy suits

• Acne marks, scars (atrophic), wide pores.
• Fine wrinkles, uneven texture.
• Hyperpigmentation, dullness.
• Thinning hair (specialised mesotherapy on the scalp).
• A need for skin hydration.

Combining with peels and other treatments

Experienced beauticians often combine:

• Peel + microneedling: 2 weeks apart. The peel prepares the skin, microneedling stimulates regeneration.
• Microneedling + mesotherapy: in the same visit — microneedling opens channels in the skin so the cocktail absorbs better.
• PRP + microneedling: the classic “vampire facial”.

Before the procedure

• 1 week before: avoid retinoids and hydroquinone.
• 3 days before: no facial peel or waxing.
• 24 h before: do not drink alcohol.
• On the day of the visit: come without makeup.

After the procedure

• Day 0–1: skin is red, mild swelling. Use nourishing creams (niacinamide, hyaluronic acid).
• Day 2–4: mild flaking. Wash with a gentle cleanser.
• Day 5+: skin tone improves, glow appears.
• SPF 50+ mandatory for 2 weeks.
• Avoid the sauna, tanning bed and intense exercise for 48 h.

Who it is not suitable for

• Active acne (with a severe breakout).
• Active herpes phase.
• Blood clotting disorders, anticoagulants.
• Pregnant and breastfeeding women.
• Isotretinoin treatment within the last 6 months.

Where to find a trustworthy clinic

• Check the Health Board's register of activity licences.
• Ask for the device name and model — ageing dermapen devices do not deliver results.
• The specialist's training certificate (Dermapen, Vivace, Morpheus8 brand training).

Where to go next

• Chemical peel — an alternative to microneedling
• Acne treatment in Estonia
• Anti-aging care 2026
• All facial care providers in Estonia
• Beauty clinics in Tallinn
• The full beauty clinic directory

Korduma kippuvad küsimused